These are, nevertheless, of little advantage in situations where Hh signaling pathway dysregulation is mediated by results on signaling elements downstream of Smo, such as for example suppressor of fused homolog (Sufu) or GLI family members zinc finger (GLI) protein, or by increased appearance of GLI1 through Hh-independent systems (10, 11)
These are, nevertheless, of little advantage in situations where Hh signaling pathway dysregulation is mediated by results on signaling elements downstream of Smo, such as for...